Typical treatment options for nausea and vomiting in pregnancy include Ondansetron (Zofran), which is the most common antiemetic used in pregnancy, Promethazine (Phenergan), and Metoclopramide (Reglan). Another commonly recommended non-prescription medication is diphenhydramine (Benadryl) which is an antihistamine that can be used to relieve pregnancy-related nausea and vomiting.